Fig. 3: Fine mapping and novel association for LDL-C. | Nature Communications

Fig. 3: Fine mapping and novel association for LDL-C.

From: Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Fig. 3

a Locuszoom (http://locuszoom.org/) plots showing LDL-C association around the LDLR region. The plot on top is based on the Prins et al. 201748 study (N = 9961). The 95% credible set in this study included over 40 SNPs (inferred using FINEMAP based results from CausalDB (http://mulinlab.org/causaldb/)). The bottom plot shows the same region in the AWI-Gen Stage 1 GWAS (N = 10,603). Here, the region is represented by a much narrower peak and the 95% credible set, inferred using FINEMAP, includes only two SNPs. b Locuszoom plot showing associations around the GATB region in the Stage 1 (top) (N = 10,603) and Stage 2 (bottom) (N = 23,718) analysis. Although, the lead SNP from Stage 1 GWAS, rs35804417 (pointed to by blue arrow), missed genome-wide significance, a set of SNPs, with the lead SNP rs6845395 (purple diamond), from the neighbouring FH1P1A gene was found to be significant in the Stage 2 GWAS.

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