Fig. 5: Transferability of Polygenic Risk Score (PRS) Models derived from a sub-Saharan African, an European and a Multi-ancestry GWAS to the AWI-Gen dataset.

Plots showing additional variance explained (%R²) by each PRS for (a) LDL-C, (b) TC, (c) TG and (d) HDL-C in the AWI-Gen validation dataset (N = 7103). PRS based on sub-Saharan African discovery dataset (AFG, N = 13,115 individuals)⁷ is shown in blue, European (GLGC, N = 188,577 individuals)¹⁵ in yellow and Multi-ancestry (PAGE, N = 49,839 individuals)³⁶ in red. Number of SNPs in each PRS is shown below and P-values (two-tailed estimates using PRSice2) are shown over the bars. All the PRS were significant for all lipid traits indicating transferability. However, the sub-Saharan African and Multi-ancestry PRS models had higher predictive accuracy compared to the European model. PRS stratification of (e) LDL-C, (f) TC, (g) TG and (h) HDL-C. Point range-plots comparing the difference in lipid-trait mean (mmol/L) of the upper PRS decile from the lowest, stratified by the discovery datasets are shown. The error bars show mean ± 95% confidence intervals. Additional details in Supplementary Data 8.