Fig. 6: Heterogeneity of effect size and minor allele frequencies of two LDL-C association signals in African datasets. | Nature Communications

Fig. 6: Heterogeneity of effect size and minor allele frequencies of two LDL-C association signals in African datasets.

From: Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Fig. 6

(a), (c) show effect size and MAF for rs7412 and (b), (d) show effect size and MAF for rs4788609. The GWASs compared include AWI-Gen West African (A_WEST) GWAS (N = 3763), AWI-Gen East African (A_EAST) GWAS (N = 1755), AWI-Gen South African (A_SOUTH) GWAS (N = 5085), Uganda Genome Resource (UGR) study (N = 6407), Africa-America Diabetes Mellitus (AADM) study (N = 4116), Durban Diabetes (DDS) (N = 1117) Study and Durban Case Control (DDC) Study (N = 1475). The West African populations are shown in orange, East African populations in green and Southern African populations in blue. AADM due to inclusion of both East and West African participants is shown in two colours. Error bars show effect sizes ± standard errors.

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