Fig. 4: Benchmarking of dual knockouts by pan-essential paralog pair.
From: Comparative optimization of combinatorial CRISPR screens
a–c The ROC-AUC curves derived from pan-essential and nonessential paralog pairs across distinct libraries in (a) IPC298, (b) MELJUSO, and (c) PK1. AUC values are indicated in parentheses. d Correlation between the average LFC of dual knockouts with inverted positions of sgRNAs in IPC298. Pearson’s correlation coefficient is indicated (r value) in black. Percent of pan-essential paralog pairs with LFC less than −1 for both sgRNAs in positions are indicated in red. Pan-essential paralog pairs are annotated by red dots. Source data are provided in the Source Data File.
