Fig. 7: Evidence for an evolutionarily conserved m6A regulatory code in mouse and human.
From: Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences
a, b Scatter plot of modeled probability for the m6A sites (n = 100,000) in mouse chromosome 9 (a) or human chromosome 9 (b) using mouse iM6A model versus human iM6A model. Both mouse and human iM6A models were trained independently on data of other chromosomes except chromosome 9 in mouse and human genome respectively. Each dot represented one site in mouse chromosome 9 discovered by both models, and the labeled axes provided the probability values for that site by the two models. c The protein sequences conservation of METTL3, METTL14, WTAP, and VIRMA between human and mouse. The full length of the proteins was illustrated by the gray box with individual different amino acids marked as black lines. d Cis-elements that regulate m6A deposition locate majorly within 50 nt downstream of m6A sites. The m6A enhancers mostly contained part of the RRACH motif; the m6A silencers mostly contained the CG/GT/CT dinucleotides.
