Fig. 6: Hydrolytic degradation in physiological conditions of P(AAm-co-BMDO) copolymers, PLA, and PLGA. | Nature Communications

Fig. 6: Hydrolytic degradation in physiological conditions of P(AAm-co-BMDO) copolymers, PLA, and PLGA.

From: Vinyl copolymers with faster hydrolytic degradation than aliphatic polyesters and tunable upper critical solution temperatures

Fig. 6

a Evolution of the SEC chromatograms at different time during hydrolytic degradation in PBS (pH 7.4, 37 °C) of P(AAm-co-BMDO) copolymers (Table 2, P9–P13 and P17) as a function FBMDO: (1) P9 (FBMDO = 0, no Tcp); (2) P10 (FBMDO = 0.017, no Tcp); (3) P11 (FBMDO = 0.027, no Tcp); (4) P12 (FBMDO = 0.068, no Tcp); (5) P13 (FBMDO = 0.093, Tcp = 25 °C) and (6) P17 (FBMDO = 0.128, Tcp = 52 °C). b Evolution of the number-average molar mass, Mn, with time during hydrolytic degradation in physiological conditions (PBS, pH 7.4, T = 37 °C) of: (1) PAAm (P9), P(AAm-co-BMDO) copolymers P10–P13 and P17 and (2) PLA and PLGA; c evolution of the Mn with time during enzymatic degradation with lipases (Candida antartica, PBS, pH 7.4, T = 37 °C) of: (1) PAAm (P9), P(AAm-co-BMDO) copolymers P13 and P17 and (2) PLA and PLGA.

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