Table 1 Experimental conditions and macromolecular characteristics of P(AAm-co-MPDL) and P(AAm-co-MDO) copolymers synthesized by RAFT-mediated copolymerization of AAm and MPDL (or MDO) in anhydrous DMSO at 70 °C for 16 h.

From: Vinyl copolymers with faster hydrolytic degradation than aliphatic polyesters and tunable upper critical solution temperatures

Entry	CKA	f_CKA,0	F_CKA^a	Open CKA (%)^a	AAm conv. (%)^b	T_cp from UV (°C)^c		M_{n, NMR} ^d (g mol⁻¹)	M_{n, exp.}^e (g mol⁻¹)	Đ _exp.^e	M_{n, deg. theo.}_.^f (g mol⁻¹) (% M_n loss)	M_{n, deg.}^g (g mol⁻¹) (% M_n loss)
Entry	CKA	f_CKA,0	F_CKA^a	Open CKA (%)^a	AAm conv. (%)^b	Cooling	Heating	M_{n, NMR} ^d (g mol⁻¹)	M_{n, exp.}^e (g mol⁻¹)	Đ _exp.^e	M_{n, deg. theo.}_.^f (g mol⁻¹) (% M_n loss)	M_{n, deg.}^g (g mol⁻¹) (% M_n loss)
P0	-	0	0	0	>98	-^h	-^h	8200	28,300	1.2	-	27,500 (−2.8%)
P1	MPDL	0.2	0.038	51	>98	-^h	-^h	6600	22,300	1.3	3800 (−83%)	22,900 (+2%)
P2	MPDL	0.4	0.043	50	>98	15	-ⁱ	6500	17,800	1.2	3400 (−81%)	15,600 (−12%)
P3	MPDL	0.6	0.067	37	98	18	-ⁱ	6100	12,500	1.2	3000 (−76%)	10,000 (−20%)
P4	MPDL	0.8	0.108	44	87	38	38	8200	8300	1.2	1600 (−81%)	5700 (−31%)
P5	MDO	0.2	0.095	76	>98	-^h	-^h	16,000	29,300	1.7	1000 (−97%)	13,500 (−54%)
P6	MDO	0.4	0.18	43	93	-^h	-^h	5600	37,900	2.3	960 (−97%)	7500 (−80%)
P7	MDO	0.6	0.27	53	95	-^h	-^h	8500	53,700	3.3	540 (−99%)	6200 (−88%)
P8	MDO	0.8	0.44	43	76	-^j	-^j	7100	14,000	4.4	420 (−97%)	1700 (−87%)

^aDetermined by ¹H NMR after precipitation by: (i) integrating the 2H (–NH₂) of AAm, the 5H (aromatic protons) of open and closed MPDL (6.5–7.5 ppm), the 2H of open MPDL (4.0–4.4 ppm) and the 1H of closed MPDL (5.0–5.2 ppm) for MPDL and (ii) by integrating the 2H (–NH₂) of AAm (6.5–7.5 ppm), the 2H of open MDO (3.9–4.1 ppm) and the 4H of closed MDO (3.4–3.8 ppm) for MDO. ^bDetermined by ¹H NMR by integrating the 2H of AAm (6.02–6.24 ppm) at t = 0 and 16 h. ^cDetermined from the maximum of the first derivative of the cooling/heating curves obtained by UV-vis temperature ramp (1 °C min⁻¹) at 10 mg mL⁻¹ in deionized water. ^dDetermined by ¹H NMR after precipitation by integrating the 3H from the CH₃ moiety of the RAFT agent C12 alkyl chain (0.86 ppm), the 1H of AAm (2.1 ppm) and: (i) the 2H of open MPDL (4.0–4.4 ppm) and the 1H of closed MPDL (5.0–5.2 ppm) or (ii) the 2H of open MDO (3.9–4.1 ppm) and the 4H of closed MDO (3.4–3.8 ppm). Note that this method is only accurate for high-living chain fractions. ^eDetermined by SEC in DMSO with 100 mM LiBr. ^fDetermined according to M_{n, deg. theo} = ([1/(open CKA × F_CKA)]–1) × MW_AAm + MW_CKA, with MW being the molecular weight of the considered monomer. ^gDetermined by SEC in DMSO with 100 mM LiBr after hydrolytic degradation using KOH 5 wt.% solution. ^hSamples were water-soluble at any temperature. ⁱLoss of the UCST behavior due to precipitation occurring below the UCST. ^jSamples were insoluble in water at any temperature.

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Table 1 Experimental conditions and macromolecular characteristics of P(AAm-co-MPDL) and P(AAm-co-MDO) copolymers synthesized by RAFT-mediated copolymerization of AAm and MPDL (or MDO) in anhydrous DMSO at 70 °C for 16 h.

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