Fig. 8: Gut microbiota regulates AML via alteration of intestinal barrier function and LPS blood concentration. | Nature Communications

Fig. 8: Gut microbiota regulates AML via alteration of intestinal barrier function and LPS blood concentration.

From: Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

Fig. 8

Gut microbiota disorders in AML lead to a decrease in intestinal butyrate. Decreased butyrate weakens gut barrier function by altering tight junction proteins (claudin-1, claudin-2, ZO-1). Dysregulation of intestinal barrier function allows LPS leakage into blood, which in turn promotes the proliferation of AML cells and accelerates AML progression. These effects could be reversed by treatment with butyrate or FMT.

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