Fig. 2: Single-cell transcriptome reveals distinct luminal cell subpopulations. | Nature Communications

Fig. 2: Single-cell transcriptome reveals distinct luminal cell subpopulations.

From: MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

Fig. 2

a, b Single cell census of the WT and MYC-transformed VP (a) followed by unsupervised clustering revealed four luminal subsets (b VP; n = 1 per genotype). c, d Human MYC transcript (hg19MYC) is only observed in MYC-transformed VP and mostly restricted to the luminal subsets while murine Myc transcript (mm10Myc) is expressed across cellular populations and genotypes (c VP; n = 1 per genotype) and is not correlated with hg19MYC expression in luminal cells (d VP; n = 1 per genotype; edgeR: two-sided quasi-likelihood F-test).

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