Fig. 3: CT-guided preoperative tumor labeling and visualization-guided surgery on basis of CT and eye dually visible PIDA. | Nature Communications

Fig. 3: CT-guided preoperative tumor labeling and visualization-guided surgery on basis of CT and eye dually visible PIDA.

From: Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer

Fig. 3

a, b Schematic illustration of tumor labeling by PIDA marker under CT guidance (a) and surgical resection of the labeled tumor guided by eye-visible blue PIDA (b). c CT images of a tumor-bearing rat injected with a PIDA suspension at 4 spots on the tumor periphery ([I]: 4 mg mL−1, 50 μL each) over time. Tumors were omitted for better illustration for CT images of 6 h. d Exposed orthotopic tumor sites of the rat injected with PIDA. 4 blue PIDA residues surrounding the tumor clearly determined the resection margin of the tumor. e Schematic illustration of CT-guided tumor infiltration of intratumorally injected PIDA suspension. f Tumor infiltration of PIDA nanofibers for tumor boundary determination. g–i Complete tumor infiltration of PIDA nanofibers at 2 h post the injection measured by MR imaging (g), CT imaging (h), and optical imaging (i).

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