Fig. 2: Substrate scope of amino acids. | Nature Communications

Fig. 2: Substrate scope of amino acids.

From: Catalytic asymmetric Tsuji–Trost α−benzylation reaction of N-unprotected amino acids and benzyl alcohol derivatives

Fig. 2

Reaction conditions: 1 (0.30 mmol), 2a (0.20 mmol), 3f (0.02 mmol), dppp (0.02 mmol), [Pd(C3H5)Cl]2 (0.01 mmol), tris(dimethylamino)iminophosphorane (TDMAIP, 0.20 mmol), and ZnCl2 (0.08 mmol) were stirred in mesitylene (0.5 mL) at 60 °C under the nitrogen atmosphere for indicated time. Isolated yields. The enantioselective excess (ee) was determined by HPLC. aAt 80 °C.

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