Fig. 1: Biosynthesis of sordaricin is an example of the classical norbornene forming Diels-Alder reaction in Nature. | Nature Communications

Fig. 1: Biosynthesis of sordaricin is an example of the classical norbornene forming Diels-Alder reaction in Nature.

From: Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase

Fig. 1

a DA reaction between a cyclopentadiene and a substituted olefinic dienophile yielding norbornene. b Well characterized IMDA reactions in biosynthesis of polyketides and polyketide-nonribosomal peptide hybrid natural products. HRPKS, highly reducing polyketide synthase. c Retro-biosynthetic scheme of sordarins. The numbering of cycloaraneosene follows Kudo, et al27. d BGCs for hypoxysordarin (sdn) and sordarin B (putative). Genes in sdn but absent from the sordarin B cluster are colored gray. TC, terpene cyclase; GGPPS, geranylgeranyl pyrophosphate synthase; MT, methyl transferase; HP, hypothetical protein; DH, dehydratase; GT, glycosyl transferase; SDR, short chain reductase; TF, transcription factor; FMO, flavin-dependent monooxygenase.

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