Fig. 6: Non-synonymous A-to-I editing signatures are preserved in the stiaining microniche groups.
From: Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches
Source data are provided as a Source Data file. a A-to-I editome of distant-clustered ROIs show preserved A-to-I signatures. b Tree with height clustered with physical distance between ROIs (left) and distribution of these clusters in the tissue. c A heatmap of single-base RNA editing event in selected genes related to iron mediation. d Volcano plot of fold change values of genes in samples with A-to-I-edited GPX4 variants compared to those without the variant. Microniches from four TNBC tissues (from patients B, C, D, and E) were analyzed. Blue dots indicate ferroptosis-related genes, red dots indicate upregulated genes in CSCs, and green dots indicate downregulated genes in CSCs.
