Fig. 1: 1,10-pt induces a stress response affecting RNAPII and Epl1 promoter binding.

A–D Genome browser tracks showing RNAPII (Rpb3) or H3K23 acetylation ChIP-seq read counts at the indicated genes before (t = 0) or 15 min after 1,10-pt treatment. Dashed boxes indicate promoter regions where Rpb3 binding either decreases or increases (possibly in an elongation-block state) following 1,10-pt treatment. Raw data are from Martin et al.¹. E Scatter plot comparing H3K23ac (top) and H4K8ac (bottom) at promoters 15 min following 1,10-pt treatment (y-axis) to Rpb1 ChIP-seq (all fold-change, log2) at 5 min following heat shock (x-axis) for the 400 most highly expressed genes. Pearson coefficient is indicated. Raw data are from Martin et al.¹ for H3K23ac and H4K8ac ChIP-seq and¹³ for Rpb1 ChIP-seq. F Scatter plot comparing two replicates (Rep1 and Rep2) measuring log2 fold change of Epl1 ChIP-seq signal before and after 1,10-pt treatment at all RNAPII promoters (gray dots) or at 562 promoters displaying high Epl1 binding in the absence of 1,10-pt (red dots), selected by Martin et al.¹. Raw data are from ref. ¹.