Fig. 6: ViP/sViP signatures correlate with two distinct cardiac phenotypes in MIS-C and KD. | Nature Communications

Fig. 6: ViP/sViP signatures correlate with two distinct cardiac phenotypes in MIS-C and KD.

From: An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

Fig. 6

a Violin plots display the left ventricular ejection functions (LVEF) in KD and MIS-C patients. Statistical significance was determined by unpaired two-sided Student’s t-test. b–d Correlation tests (two-sided test of the slope of the regression line compared to zero) between LVEF (Y-axis) and gene signature scores on the X-axis [either ViP (b), sViP (c), or a IL15/IL15RA composite (d)] are displayed as a scatter plot and significance was calculated and displayed as in Fig. 5f. The confidence interval around the regression line is indicated with shades. e Bar and violin plots show how a IL15/IL15RA compositive score varies between KD samples. The score classifies KD-AV with giant CAAs from control (KD-CV) samples with a ROC AUC 0.95. Welch’s two sample unpaired two-sided t-test is performed on the composite gene signature score to compute the p values. In multi-group setting each group is compared to the first control group and only significant p values are displayed.

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