Fig. 2: Reaction optimization.
From: Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds
Reaction conditions: 1a (0.2 mmol), 2a (0.4 mmol), AlEt3 (1 mol/L in hexane, 0.08 mmol), toluene (0.4 mL) under N2 for 12 h. Yield was determined by 1H NMR. cod = 1,5-cyclooctadiene. Et = ethyl. Cy3P = triisopropylphosphine. BINAP = 2,2’-bis(diphenylphosphino)-1,1’-binaphthalene. IPr = 1,3-bis(2,6-diisopropylphenyl)-2,3-dihydro-1H-imidazole. SIPr = 1,3-bis (2,6-diisopropylphenyl)imidazolidine. IMes = 1,3-dimesityl-2,3-dihydro-1H-imidazole. iBu = isobutyl. tBu = tert-butyl. Mes = 2,4,6-trimethylphenyl. Dipp = 2,6-diisopropylphenyl.
