Fig. 6: Mechanism of translation repression by poly-PR and poly-GR (purple): binding to the 60S (blue) polypeptide tunnel is consistent with perturbation of translation initiation (this work and ref. 44) and binding to 80S inhibits translation elongation (this work and ref. 41). | Nature Communications

Fig. 6: Mechanism of translation repression by poly-PR and poly-GR (purple): binding to the 60S (blue) polypeptide tunnel is consistent with perturbation of translation initiation (this work and ref. 44) and binding to 80S inhibits translation elongation (this work and ref. 41).

From: Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

Fig. 6

Poly-GR may also inhibit translation by binding to a secondary site at the interface of the 40S and 60S subunit thereby interfering with intersubunit rearrangements.

Back to article page