Fig. 1: Structure of the SUR2 subunit in complex with KATP opener and Mg-nucleotides.
From: Structural identification of vasodilator binding sites on the SUR2 subunit
a–c Cryo-EM density map of SUR2B in complex with Mg-nucleotides and levcromakalim (Lev), viewed from the side. The approximate position of the lipid bilayer is indicated by gray bars. TMD1-NBD1, TMD2-NBD2, Lev, Mg-ATP, Mg-ADP, and cholesteryl hydrogen succinate (CHS) are colored in pink, blue, yellow, cyan, orange, and brown, respectively. For better visualization of the position of Lev, a fragment of TMD2 in front of Lev was omitted in (b); the residual detergent densities are also omitted. d Empty KATP opener-binding site in the cryo-EM map of the SUR2B subunit in complex with Mg-nucleotides is outlined by dashed lines. The map is shown as mesh and the protein is shown as sticks. e P1075 density (yellow) in the SUR2B subunit (gray). f Lev density (orange) in the SUR2B subunit (gray).
