Fig. 4: Structural comparisons of the NBDs of ABCC family members.
From: Structural identification of vasodilator binding sites on the SUR2 subunit
a, b Close-up views of EM densities at the degenerate site and the consensus sites. c Bottom view of the NBD1 and NBD2 of SUR2B in the Mg-nucleotides and P1075-bound state. ATP and ADP molecules are shown as sticks. Mg2+ are shown as green spheres. The color scheme is the same as that in Fig. 1. The Cα distances between glycine in the Walker A motif and serine (cysteine at the degenerate site) in the ABC signature motif are shown as dashed lines. d NBD structures of SUR1. View of SUR1 (PDB ID: 7W4O) NBDs from the bottom. ATP and ADP molecules are shown as sticks. Cα distances between glycine in the Walker A motif and serine (cysteine at the degenerate site and alanine at the consensus site) in the ABC signature motif are shown as dashed lines. e NBD structures of CFTR. View of CFTR (PDB ID: 5W81) NBDs from the bottom. ATP and ADP molecules are shown as sticks. Cα distances between glycine in the Walker A motif and serine in the ABC signature motif are shown as dashed lines. f NBD structures of MRP1. View of MRP1 (PDB ID: 6UY0) NBDs from the bottom. ATP and ADP molecules are shown as sticks. Cα distances between glycine in the Walker A motif and serine (cysteine at the degenerate site and alanine at the consensus site) in the ABC signature motif are shown as dashed lines.
