Fig. 6: Model for the KATP channel activation by Mg-nucleotides and KATP opener.
From: Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides
a–c Side view of the cartoon model of the KATP channel. For simplicity, a pair of Kir6 subunits and one SUR2 subunit are shown. Kir6, TMD0, TMD1-NBD1, TMD2-NBD2, Mg2+, ATP, ADP, insulin secretagogue (IS), and KATP opener (KCO) are colored in green, yellow, pink, blue, dark green, cyan, orange, purple, and red, respectively. The flexible KNtp in the Mg-nucleotide and KATP opener-bound state is outlined by dashed lines.
