Fig. 1: Mechanical modeling of mitochondria inner membrane reveals the role of constrains at cristae junctions in cristae morphogenesis. | Nature Communications

Fig. 1: Mechanical modeling of mitochondria inner membrane reveals the role of constrains at cristae junctions in cristae morphogenesis.

From: Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS

Fig. 1

a Schematic diagram showing cristae formation. The structure of cristae, cytosol, outer membrane, inner membrane, mitochondria matrix and cristae junctions (CJs)-located proteins are illustrated. CJ-located proteins exerted tethering force on CJs. b Mechanical modelling of cristae growth under normal conditions. CJ-located proteins exerted tethering force on CJs and initiated inner membrane ridges. Color bar: membrane stress. c Lack of key CJ-located protein resulted in reduced sites of tethering force and less CJs. Left: schematic diagram showing CJ with tethering site. Right: mechanical modelling of decreased CJs’ number. Color indicates membrane stress. d Reduced tethering force induced wider CJs. Left: schematic diagram showing CJ with reduced tethering forces. Right: mechanical modelling of wider CJs. Color indicates membrane stress. e Asymmetric tethering force induced tilted crista. Left: schematic diagram showing CJ with symmetric tethering force. Right: mechanical modelling of cristae with different angles. Color indicates membrane stress.

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