Fig. 3: Differentially accessible regions in aged HSPCs.
From: Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells
a The number of DARs in aged HSPCs compared with their counterparts (upper panel). Percentages of each cluster subtype based on clustering in Fig. 2a (middle panel) and annotation (lower panel) of all DARs. DARs were calculated using DESeq2 using generalized linear model and a cutoff p < 0.001 was used to define the DARs. No adjustments were made for multiple comparisons. b Heatmap showing the enrichment score [z-scores of −log (P values)] of the transcription factor binding motifs at accessible peaks detected in ATAC-seq in each young and aged HSPC fraction. P values were derived from Hypergeometric tests of motif analysis. No adjustments were made for multiple comparisons. Source data are provided as a Source Data file.
