Fig. 2: Comparison of aRML and 263K prions. | Nature Communications

Fig. 2: Comparison of aRML and 263K prions.

From: Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains

Fig. 2

a Ribbon diagram of aRML core (stack of 5), with structural motifs as colored. b Overlay of aRML and 263K cores. c Contour EM density maps of aRML and 263K. Green arrows indicate peripheral unassigned densities associated with cationic residues in the N-terminal lobes of both strains, but absent in the aRML C-terminal lobe, consistent with aRML’s lack of glycans and glycolipid anchors. d Lateral views of aRML and 263K EM maps (stacks of 3) with stick models embedded in top rung. Arrowhead indicates protrusion of anvil-like head of the N β-arch. Underneath is a ribbon overlay of aRML and 263K monomers indicating differences in planarity.

Back to article page