Fig. 2: ABR-001 is a specific nuclease for genome editing.
From: Engineered Cas12i2 is a versatile high-efficiency platform for therapeutic genome editing
a Representative off-target discovery of ABR-001 and SpCas9 by TTISS at VEGFA Target 1. b–d TTISS analysis across 6 test loci for each of 3 genes. Teal (ABR-001) and blue (SpCas9) bars show average on-target indel activity for n = 2 replicates, each indicated by an outlined circle. Doughnut plots depict proportion of detected cleavage sites for each nuclease. Off-targets are shown as light gray wedges, while the on-target site is highlighted in teal (ABR-001) or blue (SpCas9). Centered numerical values represent fraction of on-target TTISS reads. Source Data are provided as a Source Data file.
