Fig. 10: Summary of the overall findings. | Nature Communications

Fig. 10: Summary of the overall findings.

From: PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression

Fig. 10

PRRX1 is the master transcription factor (mTF) that determines the lineage of highly pro-tumorigenic cancer-associated fibroblasts (CAFs) with a myofibroblastic phenotype through remodeling a super-enhancer landscape. Targeting the mTF, PRRX1 belonging to the CAF subgroup with a myofibroblastic phenotype may be a promising cancer treatment strategy.

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