Fig. 2: Whole-genome-wide recent selection signatures of the Han Chinese population by singleton density score (SDS) analysis.
From: Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project
a Manhattan plot of the natural selection signatures from the WGS data of the Han Chinese individuals. The y-axis represents the -log10 (P) of the two-tailed p values for standardized SDS z-scores. The horizontal red line indicates the significance threshold (p < 5 × 10−8). b The derived allele frequency (DAF) of SNVs with significant selection signatures for different populations. The WBBC-Han is all the Han Chinese individuals sequenced by whole-genome sequencing (WGS) in the WBBC cohort. North, Central, South, and Lingnan are the four Han subgroups. EAS, SAS, EUR, AMR, and AFR come from the 1000 Genome Project (1KG). c The inferred allele frequency trajectory for the derived alleles at rs3819197, rs1229984, and rs671 over the past 9500 years from the ancient individuals of East Asia. The dot indicates the allele frequency in each generation (25 years/generation). Source data are provided as a Source Data file.
