Fig. 5: Application of the method in modification of drug molecules. | Nature Communications

Fig. 5: Application of the method in modification of drug molecules.

From: Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones

Fig. 5

Reaction conditions: 1 (1.5 equiv), 2 (0.05-0.1 mmol, 1.0 equiv), B (20 mol%), PC-3 (1 mol %) and Cs2CO3 (2.0 equiv) in MeCN, blue LED (Kessil PR160 series, λmax = 427 nm), Ar atmosphere, 30–40 °C, 24 h. a Pre-prepared acyl imidazoles were used. b Blue LEDs (Kessil PR160 series, λmax = 440 nm) were used. c Yield in parentheses is obtained by using pre-prepared acyl imidazole as starting material.

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