Fig. 2: Comparing ATLAS with MIC histograms from EUCAST: from the worst to best correspondences.
From: Seeking patterns of antibiotic resistance in ATLAS, an open, raw MIC database with patient metadata
A If an MIC (minimal inhibitory concentration) histogram from EUCAST is the vector x and an analogous histogram is determined from ATLAS (by aggregating across all years) and denoted y, this heatmap shows the Euclidean distance ∥x − y∥2 for each pathogen-antibiotic (PA) pair in both databases: squares indicate distances on a colour scale, black denotes close agreement and pink denotes poor agreement, white shows no comparison can be made. Axis labels are ordered whereby the biggest ATLAS-EUCAST disagreements are generally found leftmost and uppermost. B Two MIC histograms are shown whereby the open black and green squares superimposed on A highlight S. pneumoniae and clindamycin and erythromycin as having among the biggest disagreements between ATLAS and EUCAST. C The case of S. pneumoniae and amoxycillin clavulanate is one of 10 antibiotic PA pairs for which ATLAS has resistant subpopulations according to CLSI breakpoints, but EUCAST does not (also Supplementary Fig. 25).
