Fig. 4: C. albicans undergoes transcriptional changes during infection of L. rhamnosus-colonized IECs. | Nature Communications

Fig. 4: C. albicans undergoes transcriptional changes during infection of L. rhamnosus-colonized IECs.

From: Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity

Fig. 4

a Principal component analysis of C. albicans gene expression at 6 and 24 h during in vitro infection of IECs in the presence and absence of L. rhamnosus colonization. b Volcano plots showing differentially regulated C. albicans genes at 6 and 24 hpi as a result of L. rhamnosus colonization prior to infection based on the criteria of a Log2 fold change of >1 or < −1 and a Bonferroni-corrected two-tailed moderated t-test p-value of <0.05 (dark blue and dark red) and <0.1 (light blue and light red). Source data are provided as a Source Data file. c Venn diagram analysis of the overlap in differentially expressed genes at 6 and 24 hpi. Data summarized from n = 3 and n = 4 independent experiments at 6 and 24 hpi, respectively. d PCA of C. albicans gene expression at 24 hpi during in vitro infection of IECs in the presence and absence of L. rhamnosus colonization and in the presence and absence of antibiotics.

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