Fig. 5: C. albicans undergoes transcriptional metabolic adaptations when infecting L. rhamnosus colonized epithelium. | Nature Communications

Fig. 5: C. albicans undergoes transcriptional metabolic adaptations when infecting L. rhamnosus colonized epithelium.

From: Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity

Fig. 5

a GO-term enrichment analysis of differentially regulated genes (Log2 fold change >1 or < −1 and p < 0.1) analysed with the GO-term finder on the Candida Genome Database website and reduced with the Revigo program (http://revigo.irb.hr/) (similarity: Tiny (0.4)). Significantly enriched GO terms are plotted based on the –Log10 p-value from the Bonferroni-corrected hypergeometric distribution. Data summarized from n = 3 at 24 hpi. Source data are provided as a Source Data file. b Heatmap highlighting the transcriptional regulation of C. albicans metabolic genes as a result of L. rhamnosus colonization at 6 and 24 hpi. Legend colour represents the Log2 fold change of the regulation in presence vs. absence of L. rhamnosus. The asterisks (*) represent significance, based on the criteria of a Log2 fold change of >1 or < −1 and a moderated t-test, Bonferroni-corrected two-tailed p-value of <0.05.

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