Fig. 7: Screening of C. albicans deletion mutants.

a Ability of deletion mutants to induce necrotic cell damage of IECs assessed by LDH activity in the supernatant at 24 hpi. Data are shown as the mean and standard deviation (SD) with dots showing the individual replicates (n = 3–11 biological replicates). Deletion mutants were compared to the wild-type control using a one-way ANOVA and Dunnett’s Multiple Comparison post-hoc analysis. Mutants with a significantly increased or decreased damage potential (dark blue, p-value ≤ 0.05; light blue, p-value ≤ 0.1) are labelled (see Supplementary Table 4 for exact p-values). Horizontal lines correspond to the mean of the damage induced by the wild-type ± SD. b Growth rates of the ptp3Δ/Δ mutant with significantly reduced growth (blue line) compared to the parental strain (black line) in KBM. Lines represent the mean and SD of n = 3 independent experiments and were compared for significance using a two-way Repeated Measures ANOVA, * = p 0.0188. Source data are provided as a Source Data file. c Representative images of the ptp3Δ/Δ deletion mutant and the parental strain morphologies, after 24 h incubation in KBM at 37 °C with 5% CO₂.