Fig. 2: Both ssDNA and nucleotide cofactor binding are essential for DISARM function.
From: Structural basis for broad anti-phage immunity by DISARM
a Overall structure of DrmAB:DNA:ADP. Boxes indicate regions featured in panels (b, e). b Close-up view of DrmA:DNA interactions. No interactions between DrmB and DNA are observed. c Schematic of DNA-protein contacts colored by protein domain. d Effect of mutagenesis of DrmA DNA-interacting residues on DISARM anti-phage activity. Points correspond to three biological replicates, with mean and standard deviation shown. Source Data are provided as a Source Data file. e Close-up view of DrmA:ADP interactions. f Effect of mutagenesis of DrmA ADP-interacting residues on DISARM anti-phage activity. Points correspond to three biological replicates, with mean and standard deviation shown. Source Data are provided as a Source Data file.
