Table 2 PROVEAN scores of strong candidate mutations and other mutations previously described as adaptive to human and/or non-human hosts.

From: Transmission of SARS-CoV-2 from humans to animals and potential host adaptation

Protein

Mutation

Potentially adaptive to

Reference

PROVEAN score

ORF1ab

NSP9_G37E

mink

present study

−5.108*

 

NSP3_L1035F

deer

−0.808

Spike

N501T

mink

54, present study

0.746

 

F486L

55,54, present study

−0.035

 

Y453F

29,54,30, present study

−0.393

 

N501Y

Rodents, Humans

18,94

−0.090

 

L452R

Humans

18

0.559

 

E484K

0.128

 

D614G

0.598

 

P681R

0.741

ORF3a

L219V

mink

present study

0.276

  1. Mutations that were predicted by PROVEAN to be deleterious to protein function are indicated by an asterisk (*).
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