Fig. 2: TWIK1 conduction pathways at high and low pH.
From: Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter
a, b Structures of TWIK1 at (a) pH 7.4 and (b) pH 5.5 with the surface of conduction pathways shown in gray. c Radius of the central pore as a function of distance along the conduction pathway. Positions of the selectivity filter, lipid block at low pH, K+ coordination sites S0-S4, and T123 are indicated. d Radius of the extracellular ion pathways as a function of distance from the central conduction axis.
