Fig. 2: Circular presentation of loci associated with circulating lipid species identified in our Discovery GWAS. | Nature Communications

Fig. 2: Circular presentation of loci associated with circulating lipid species identified in our Discovery GWAS.

From: Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

Fig. 2

The −log10(P) for genetic association with lipid species are arranged by chromosomal position, indicated by alternating blue and green points. Association P-values are truncated at P < 1 × 10−60. Genome-wide significance (P < 5 × 10−8) is indicated by the red line. For details about significant associations, see Supplementary Data 2, 3. Genes identified in our candidate gene analysis are highlighted in blue, otherwise the closest gene is indicated in black. The purple band indicates lipid-loci that co-localise with coronary artery disease (CAD) or show association with CAD after adjusting for clinical lipids. The inner circle shows a Fuji plot of SNP-lipid associations, coloured by broad lipid category. Colour keys representing broad lipid categories are indicated in the plot centre. Chromosomes are indicated by numbered panels 1–22.

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