Fig. 4: Identification of putative causal genes using genetic prioritisation and knowledge-based approaches.

Assignment of putative causal genes was performed using the ProGeM framework, incorporating genetic-based prioritisation (bottom-up), and biological knowledge-based approaches (top-down). a Venn diagram showing the number of loci with annotations for candidate genes using the distinct approaches and the overlap. Top-down annotations were divided into lipid-specific databases and generic databases. b Venn diagram of distinct genes identified in genetic-based prioritisation analysis. c Summary of putative causal genes with overlapping annotations for closest gene, protein consequences, eQTL and meQTL (left). Summary of putative causal SNP-gene pairs for which pQTL evidence was identified (right). eQTL expression quantitative trait loci, meQTL methylation quantitative trait loci, pQTL protein quantitative trait loci.