Fig. 1: Frequency of NRAS mutants in human melanoma parallels tumorigenic potential in mice.
From: Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation
a Frequency of NRAS mutations in the TCGA PanCancer Atlas dataset for human cutaneous melanoma. Melanoma-free survival (b), total tumor burden (c), and tumor growth rates (d) for mice expressing the indicated melanocyte-specific NRAS mutants. Tumor burden and growth rate data are presented as mean values +/− SD. The following number biologically independent animals were evaluated per genotype (61R = 72, 61K = 19, 61L = 17, 61H = 17, 61P = 16, 61Q = 22). Log-rank (Mantel–Cox) (b) or ANOVA (c, d) with a Tukey’s multiple comparisons test was used to compare measurements between each genotype. TNX/X samples statistically different from TN61R/R are indicated in the figure. Adjusted p-values for all comparisons can be found in Supplementary Table 1a. * p < 0.05, ** p < 0.01, ‡ p < 0.0001. Source data are provided as a Source Data file.
