Fig. 2: Observed tumor mutational signature profiles for 19 CRCs from germline biallelic MUTYH pathogenic variant carriers, and 17 CRCs carrying more than one MUTYH pathogenic or potentially pathogenic variant but not two pathogenic variants (potential biallelic). | Nature Communications

Fig. 2: Observed tumor mutational signature profiles for 19 CRCs from germline biallelic MUTYH pathogenic variant carriers, and 17 CRCs carrying more than one MUTYH pathogenic or potentially pathogenic variant but not two pathogenic variants (potential biallelic).

From: Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures

Fig. 2

All the CRCs from the germline biallelic MUTYH PV carriers exhibit dominant SBS18 and/or SBS36 tumor mutational signature. Source data are provided as a Source Data file.

Back to article page