Fig. 5: Somatic mutation landscape of the 19 CRCs from biallelic MUTYH pathogenic variant carriers, as well as the 3 CRCs from carriers of variants of uncertain clinical significance that were reclassified as likely pathogenic in this study. | Nature Communications

Fig. 5: Somatic mutation landscape of the 19 CRCs from biallelic MUTYH pathogenic variant carriers, as well as the 3 CRCs from carriers of variants of uncertain clinical significance that were reclassified as likely pathogenic in this study.

From: Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures

Fig. 5

The 40 most commonly mutated CRC genes48 are included, as well as known CRC genes ALK, CSMD1, POLE, and POLD1. KRAS was found to be significantly more commonly mutated in our biallelic MUTYH carrier CRCs. Source data are provided as a Source Data file. AgeDx age of diagnosis, TMB tumor mutational burden (mutations/Mb), TMS tumor mutational signature.

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