Fig. 5: Rare variants in PDE3B selectively associate with fat distribution in female participants.
From: Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
A mask combining predicted loss-of-function variants and missense variants predicted to be deleterious by 5 out of 5 in silico prediction algorithms in PDE3B associated with GFATadj in females with exome-wide significance (Supplementary Data 15). Effect sizes with 95% confidence intervals are plotted for carrier status. Linear regressions were adjusted for age, age squared, imaging center, genotyping array, and the first ten principal components of genetic ancestry (Supplementary Data 16). Note that the carrier counts are with respect to individuals who had “adj” traits available. For the other six traits, the carrier counts are 26 carriers/9616 participants for males and 25 carriers/9879 participants for females.
