Fig. 6: Enrichment of VATadj, ASATadj, and GFATadj genome-wide polygenic scores in tails of the distribution.
From: Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
For each fat depot “adj” trait, a polygenic score was trained using LDpred2 on 70% of the studied cohort and a 10% validation cohort was used to determine the optimal set of hyperparameters. Results in this figure correspond to the 20% imaged and testing set (N = 7795). Supplementary Fig. 18 shows the full distribution of each polygenic score in each tail of VATadj, ASATadj, and GFATadj.
