Fig. 1: Intermediate chemotypes in the evolution of natural product biosynthetic gene clusters (BGCs).
From: Bifurcation drives the evolution of assembly-line biosynthesis
a A cartoon demonstrating the three main models of gene cluster evolution depicting the transition of a fictitious BGC from chemotype A to chemotype B (coloured circles). Evolutionary processes are represented by dashed lines. b The structural diversity of the wollamides and desotamides. The d-ornithine and glycine residues, which define the wollamides and desotamides, respectively, are highlighted. The table on the right-hand side shows the variable positions of the various wollamide and desotamide congeners (NFK N-formyl kyunerine, Wol wollamide, Dsa desotamide).
