Fig. 3: Prioritized critical cell types for the 16p11.2 and 15q11-13 loci. | Nature Communications

Fig. 3: Prioritized critical cell types for the 16p11.2 and 15q11-13 loci.

From: Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder

Fig. 3

All data were analyzed from 71 bRNA-seq samples across 25 donors. A CellScore results with one-sided tests for 16p11.2 (Quadrato dataset1); clusters with FWER ≤ 0.1 in pink adjusted for multiple comparisons. B CellScore results with one-sided tests for 16p11.2 (Tanaka dataset19); clusters with FWER ≤ 0.1 in pink adjusted for multiple comparisons. C CellScore results with one-sided tests for 15q11–13 (Quadrato dataset1). D CellScore results with one-sided tests for 15q11–13 (Tanaka dataset19). E Fine-mapping identities of critical cell types for 16p11.2 (Eze dataset20); sizes of the circles represent mean gene overlaps between cell type clusters. F Fine-mapping identities of critical cell types for 16p11.2 (Velasco dataset13); sizes of the circles represent mean gene overlaps between cell type clusters. G GeneScore results for 16p11.2 (Quadrato dataset1). H GeneScore results for 16p11.2 (Tanaka dataset19).

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