Fig. 3: Substrate scope of heteroaryl ketones.

Isolated yields after chromatography are shown. The CCDC number of 43 is 2116753, 52 is 2116752. ^aThe reaction was performed under optimised condition A: ketone 1 (0.1 mmol, 1.0 equiv) and ethyl bromodifluoroacetate (0.15 mmol, 1.5 equiv), PdCl₂ (10 mol%), dpppent (12 mol%) and Na₂CO₃ (1.0 equiv) in dioxane/THF (1:2) at 120 °C for 24 h. ^bThe reaction was conducted under optimised condition A with a slight modification: bis(2-diphenylphosphinophenyl)ether (DPEPhos) (12 mol%) was used as ligand during the reaction. ^cThe reaction was performed under optimised condition B: ketone 1 (0.1 mmol, 1.0 equiv) and ethyl bromodifluoroacetate (0.15 mmol, 1.5 equiv), PdCl₂ (10 mol%), dppf (12 mol%) and K₂CO₃ (1.0 equiv) in dioxane/THF (1:1) at 130 °C for 24 h. dppf = 1,1′-bis(diphenylphosphino)ferrocene.