Table 1 Serum proteins significantly associated with prevalent AMD using logistic regression analysis.

From: A proteogenomic signature of age-related macular degeneration in blood

Protein	AMD any			AMD early^a			AMD late
	β-value	P-value	P adj.^b	β-value	P-value	P adj.^b	β-value	P-value	P adj.^b
NDUFS4	−0.298	1.4E-17	7.3E-14	−0.260	3.0E-12	1.4E-08	−0.562	2.7E-14	1.4E-10
CFHR1	0.194	4.8E-09	2.5E-05	0.157	3.7E-06	0.01617	0.483	1.0E-09	5.0E-06
FUT5	0.180	1.2E-08	0.00016	0.160	1.7E-06	0.00747	0.352	7.5E-07	0.00329
TST	−0.235	2.6E-11	1.3E-07	−0.218	8.1E-09	3.5E-05	−0.353	1.2E-06	0.00544
BAMBI	0.177	5.0E-07	0.00255	0.158	8.2E-07	0.00357	0.138	0.06560	ns
BPIFB1	0.193	3.1E-08	0.00016	0.176	1.9E-06	0.00733	0.271	0.00022	ns
CEBPB	0.173	9.7E-07	0.00489	0.171	2.6E-06	0.01239	0.189	0.01393	ns
ST6GALNAC1	0.161	1.1E-06	0.00591	0.167	1.1E-06	0.00465	0.102	0.13511	ns
DLL3	0.190	1.8E-07	0.00093	0.188	1.4E-06	0.00536	0.170	0.01847	ns
UTS2	0.158	4.8E-06	0.02449	0.157	2.3E-05	ns	0.157	0.03319	ns
TNFRSF14	0.147	5.3E-06	0.02696	0.158	2.2E-06	0.00977	0.123	0.09463	ns
CXCL17	0.146	5.3E-06	0.02700	0.145	1.18E-05	0.04882	0.138	0.03687	ns
RGS8	0.149	5.4E-06	0.02762	0.153	7.4E-06	0.03254	0.137	0.04946	ns
RAB17	0.152	7.1E-06	0.03613	0.147	2.5E-05	ns	0.186	0.01027	ns
HNRNPC	0.143	7.4E-06	0.03769	0.137	3.0E-05	ns	0.163	0.01434	ns
CRABP1	0.156	8.7E-06	0.04415	0.159	9.5E-06	0.04178	0.148	0.05272	ns
CFHR5	0.161	1.1E-05	0.0463	0.077	0.01843	ns	0.406	3.3E-08	0.00014
RPS6KB1	0.169	2.3E-06	0.00538	0.103	0.00093	ns	0.155	0.02414	ns
ZPBP	0.159	1.1E-05	0.04729	0.155	2.6E-05	ns	0.171	0.02920	ns
KREMEN2	0.183	3.2E-06	0.01627	0.188	7.3E-06	0.02791	0.168	0.03047	ns
CCL1	0.142	2.2E-05	ns	0.154	7.4E-06	0.03254	0.177	0.01066	ns
CFP	−0.158	1.1E-05	0.04689	−0.103	0.00079	ns	−0.108	0.13210	ns
GHR	−0.156	1.1E-05	0.04343	−0.072	0.02341	ns	−0.145	0.02935	ns
LINGO1	0.162	8.0E-06	0.04634	0.120	0.00051	ns	0.172	0.01456	ns
B3GNT6	0.142	1.0E-05	0.04602	0.104	7.2E-04	ns	0.201	0.00291	ns
C2orf40	0.142	1.2E-05	0.04882	0.118	1.5E-04	ns	0.153	0.02070	ns
BCL2L1	0.147	1.2E-05	0.04782	0.127	4.9E-05	ns	0.137	0.06061	ns
BIRC2	0.107	0.00057	ns	0.086	0.00693	ns	0.321	5.0E-06	0.02279

ns not significant.
^aEarly stage AMD was defined by either Holliday et al.²² or Jonasson et al.²³. Based on either definition of early AMD, only the most significant association is reported. For more information, see Supplementary Data 2 and 3.
^bThe term P adj. refers to the P-value adjusted for the number of comparisons. All reported P-values are two-sided and derived from sex and age-adjusted logistic regression analysis.

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Table 1 Serum proteins significantly associated with prevalent AMD using logistic regression analysis.

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