Fig. 2: Distribution of Omicron BA.1 and BA.2 nAbs.
From: Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees
a–c Dot charts show the distribution of Class 1/2 (a), Class 3 (b) and Class 4 (c) nAbs against the original SARS-CoV-2 virus first detected in Wuhan and the BA.1 and BA.2 Omicron VoCs. The number and percentage of nAbs and neutralization IC100 geometric mean (black lines, light blue, orange, and green bars) are denoted on each graph. d The table summarizes the IC100 geometric mean of nAbs against Wuhan, BA.1 and BA.2 VoCs and the GM-IC100 fold-change between the Omicron variants and the ancestral Wuhan virus. e, f Dot charts show the neutralization potency, reported as IC100 (ng ml−1), of nAbs against Omicron BA.1 and their ability to cross-neutralize BA.2 (e) and of nAbs against Omicron BA.2 and their ability to cross-neutralize BA.1 (f). The number and percentage of nAbs and neutralization IC100 geometric mean (black lines) are denoted on each graph. Pie charts show the distribution of nAbs based on their ability to bind Class 1/2 (blue), Class 3 (orange), and Class 4 (dark green) regions on the RBD, as well as not-competing nAbs (gray) and NTD-targeting nAbs (cyan). g The table summarizes number and percentages of Class1/2 (blue), Class 3 (orange), Class 4 (dark green) not-competing (gray) and NTD-targeting nAbs (cyan) for BA.1, BA.2, and cross-Omicron nAbs.
