Fig. 2: Mature adipocytes from WAT serve as the major source of plasma Kyn. | Nature Communications

Fig. 2: Mature adipocytes from WAT serve as the major source of plasma Kyn.

From: Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling

Fig. 2

a Concentration of Kyn in the WAT, liver and skeletal muscle from NCD and HFD mice (n = 8–9). b The transcriptional level of Ido1 in various tissues of NCD and HFD mice were assessed by RT-qPCR analysis (n = 3). c RT-qPCR analysis for Ido1 mRNA expression in mature adipocytes and SVF originated from NCD or HFD fed mice (n = 3). d Expression level of IDO1 in mature adipocytes of NCD and HFD mice (n = 6). e IDO1 expression in visceral white adipose tissue from lean (18 ≤ BMI < 24) and subjects with obesity (BMI ≥ 28, n = 4). f Correlation analysis between BMI and IDO1 levels in human mature adipocytes (n = 22). Data were expressed as mean ± SEM. Statistical significance was assessed by two-sided Student’s t test (a, d and e), two-way ANOVA (b and c) or two-sided Spearman’s correlation (f) and significant differences were indicated with p values. Source data are provided in the Source Data file.

Back to article page