Fig. 5: Haplotype-biased mutation occurrences of lung cancer genomes.

a The number of phased blocks with an imbalance of point mutation occurrences between two haplotypes. The cases are ordered according to the proportion of the haplotype-biased regions of mutation occurrence. LUAD lung adenocarcinoma. b Comparison of the ratio of the haplotype-biased regions between LUAD and others. The p value was calculated by Wilcoxon rank sum test (two-sided, no multiple comparison adjustments). c A phased block with biased SNV occurrence as identified in case S2 (upper panel) and the mutational pattern of both the enriched and haplotype-biased mutations (lower panel). The mutation-enriched window is highlighted with a green-dashed line. d The mutational patterns of the enriched and haplotype-biased mutations compared with those of all mutations in LUAD and other hypermutator and non-LUAD cases. The number of mutations in each dataset is provided in the inset. e Association between the number of phased blocks containing three or more SVs and the maximum proportion of SVs occurring on one haplotype. f A phased block with biased SV occurrence in case S2. SV-supporting reads on this phased block were unevenly distributed to HP1. Source data are provided as a Source Data file for a–e.