Fig. 1: Booster effect of a single dose of BBV152 vaccination.

Geometric mean titers of antibodies against SARS-CoV-2 RBD were estimated by quantitative RBD-ELISA and data presented as geometric mean with 95% confidence intervals at baseline and after one dose in a RBD-ELISA-positive samples at baseline (n = 67 independent values) or b RBD-ELISA-negative samples at baseline (n = 23 independent values). c Geometric mean titers of antibodies against SARS-CoV-2 Nucleocapsid (N) were estimated by quantitative N-ELISA and data presented as GMT at baseline and after one dose in c N-ELISA-positive samples at baseline (n = 55 independent values) or d N-ELISA-negative samples at baseline (n = 31 independent values). Data were expressed as binding antibody units (BAU)/ml (international units). Dotted line indicates the lower limit of quantitation (LLOQ) which is 12 BAU/mL for RBD-ELISA and 15 BAU/mL for N-ELISA. Two-tailed P values were estimated by Wilcoxon matched-pairs signed-rank test in a–d. ns: Not significant. Source data are provided as a Source data file.