Fig. 1: Engineered probiotics for IBD treatment. | Nature Communications

Fig. 1: Engineered probiotics for IBD treatment.

From: Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

Fig. 1

a ECN was genetically engineered to produce CAT and SOD, which can scavenge ROS efficiently. Then, the engineered ECN was encapsulated by chitosan and sodium alginate through the layer-by-layer strategy (ECN-pE(C/A)2). ECN Escherichia coli Nissle 1917; ECN-pE, ECN(pET28a-T5-CAT-SOD). b ECN-pE(C/A)2 was orally delivered to the mice, and its bioavailability within the GI tract was significantly elevated with chitosan/sodium alginate coating. c ECN-pE(C/A)2 exerts a prominent palliative effect to relieve inflammatory bowel disease by eliminating ROS and regulating the intestinal flora.

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